Pep Guardiola’s men broke the 100-point barrier last season, and having already signed Riyad Mahrez this summer, will look to continue where they left off.
Manchester United, Liverpool and Chelsea have all invested in fresh talent while Tottenham are yet to sign any players.
Former Liverpool star Graeme Souness feels the next few weeks will be important for the likes of Chelsea, as they look to keep hold of Eden Hazard and Thibaut Courtois.
But Souness is backing Liverpool and United to pose the biggest threat to City in the race to be crowned champion.
“It’s very hard to retain the Premier League,” he said.
“City have quality in every position, they have the ability to go out and outspend every opposition – but Manchester United will not be happy that City are getting all the plaudits in winning the trophy. They’ll be bang at it.
“Liverpool will be stronger next year, and that makes them dangerous when you think of the firepower they have, and if Chelsea can get a proper centre-forward in I think they will be too, so long as they keep Thibaut Courtois and Eden Hazard.
“If Tottenham can invest and get a couple of genuine performers at the highest level, they will be a real danger.
“I couldn’t pick one team because I know City will be chased and harried, more than they were last year, if that’s possible. But if you were asking me the team to beat, I’d still say it will be them.”
The new Premier League season gets underway on Friday, August 10 when United host Leicester at Old Trafford (8pm).
Defending champions City face a tough opening fixture against Arsenal on Sunday (4pm).